Ndị GF na ụmụ irighiri ihe ndị na-emepụta ihe dị na PRP na-akwalite omume 4 bụ isi na gburugburu ebe obibi nke nchịkwa, dị ka mmụba, ọpụpụ, ọdịiche cell, na angiogenesis.Cytokines dị iche iche na GF na-etinye aka na nhazi nke morphogenesis ntutu na ịgbatị ntutu isi.
Mkpụrụ ndụ papilla dermal (DP) na-emepụta GF dị ka IGF-1, FGF-7, hepatocyte growth factor, na vascular endothelial growth factor nke na-ahụ maka ịnọgide na-enwe ntutu isi na akụkụ anagen nke usoro ntutu isi.Ya mere, ihe nwere ike ime ga-abụ imeziwanye GF ndị a n'ime sel DP, nke na-agbatị oge anagen.
Dika nyocha nke Akiyama et al mere, ihe na-eme ka uto nke epidermal na ihe na-agbanwe agbanwe na-etinye aka n'ịhazi uto na ọdịiche nke mkpụrụ ndụ na-egbuke egbuke, na ihe na-emepụta platelet nwere ike inwe ọrụ ndị metụtara ya na mmekọrịta dị n'etiti ọkpụkpụ na anụ ahụ jikọtara ya. malite na follicle morphogenesis.
N'akụkụ GFs, usoro anagen na-arụkwa ọrụ site na Wnt/β-catenin/T-cell factor lymphoid enhancer.N'ime mkpụrụ ndụ DP, ntinye nke Wnt ga-eduga n'ịba ụba nke β-catenin, nke, na-ejikọta ya na T-cell factor lymphoid enhancer, na-arụkwa ọrụ dị ka onye na-arụ ọrụ nke ederede ma na-akwalite mmụba, nlanarị, na angiogenesis.Mkpụrụ ndụ DP na-ebute ihe dị iche iche na ya mere mgbanwe site na telogen gaa na oge anagen.Ngosipụta β-Catenin dị mkpa na mmepe follicle mmadụ yana maka okirikiri uto ntutu.
Ụzọ ọzọ e gosipụtara na DP bụ ịgbalite kinase nke na-achịkwa mgbaàmà extracellular (ERK) na protein kinase B (Akt) nke na-akwalite ndụ cell ma gbochie apoptosis.
Aghọtaghị usoro ziri ezi nke PRP na-akwalite uto ntutu.Iji chọpụta usoro ndị nwere ike ime, Li et al, mere nchọpụta a haziri nke ọma iji nyochaa mmetụta PRP na ntutu isi na-eji in vitro na ụdị vivo.Na ụdị in vitro, a na-etinye PRP arụ ọrụ na mkpụrụ ndụ DP mmadụ nwetara site na akpụkpọ anụ akpụkpọ anụ nkịtị.Nsonaazụ gosipụtara na PRP mụbara mmụba nke mkpụrụ ndụ DP mmadụ site n'ịkwalite akara ERK na Akt, na-eduga na mmetụta antiapoptotic.PRP mụbara ọrụ β-catenin na okwu FGF-7 na sel DP.Banyere ụdị in vivo, ụmụ oke etinyere na PRP arụ ọrụ gosipụtara mgbanwe telogen-to-anagen ngwa ngwa ma e jiri ya tụnyere otu njikwa.
N'oge na-adịbeghị anya, Gupta na Carviel tụpụtakwara usoro maka omume PRP na follicles mmadụ nke gụnyere "mwepụta nke Wnt / β-catenin, ERK, na Akt ụzọ akara na-akwalite ndụ cell, mmụba, na ọdịiche."
Mgbe GF jikọtara ya na onye na-anabata GF onye nta akụkọ ya, akara ngosi dị mkpa maka nkwupụta ya na-amalite.Onye nnabata GF-GF na-eme ka ngosipụta nke ma akara Akt na ERK.Nkwalite nke Akt ga-egbochi ụzọ 2 site na phosphorylation: (1) glycogen synthase kinase-3β nke na-akwalite mmebi nke β-catenin, na (2) Bcl-2 na-akwalite ọnwụ, nke na-ahụ maka ịmepụta apoptosis.Dị ka ndị edemede kwuru, PRP nwere ike ịbawanye vascularization,gbochie apoptosis, ma gbatịa ogologo oge nke usoro anagen.
Oge nzipu: Ọgọst-24-2022